I did a quick experiment with Python 3.7 and pipenv and the LabVIEW 2021 beta. It does look like there might be a work around way to get a virtual environment to work with the new Python path variable on Open Python Session.
First, you will need to copy the python37.dll into the Scripts directory of your virtual environment. Then also you will need to modify the python system path to include your virtual environment folders and remove the default system \lib\site-packages folders.
Hopefully this information makes it easier to potentially complete this idea
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Bill Eisenhower
Certified LabVIEW & TestStand Developer